Description

Methyl 4-(Difluoromethoxy)-5-Methoxy-2-Nitrobenzoate is a high-purity, advanced pharmaceutical intermediate characterized by its distinct difluoromethoxy and nitro-substituted benzoate structure. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modifications. It is primarily sought by research institutions and manufacturers in the global pharmaceutical and agrochemical industries engaged in developing novel small-molecule drugs and crop protection agents.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block for the development of new drug candidates, especially in medicinal chemistry programs.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides and pesticides, leveraging its unique fluorinated aromatic structure.
• Organic Synthesis & Process Chemistry: Employed in laboratory-scale and pilot-scale reactions for constructing complex aromatic ethers and esters.
• Material Science Precursor: Potential use in the development of specialty polymers and advanced organic materials with specific electronic properties.

Basic Information

Product Name	Methyl 4-(Difluoromethoxy)-5-Methoxy-2-Nitrobenzoate
CAS No.	923690-09-9
Molecular Formula	C10H9F2NO6
Molecular Weight	277.18 g/mol
Synonyms	4-(Difluoromethoxy)-5-methoxy-2-nitrobenzoic acid methyl ester; Methyl 4-(difluoromethoxy)-5-methoxy-2-nitrobenzoate; Benzoic acid, 4-(difluoromethoxy)-5-methoxy-2-nitro-, methyl ester; 2-Nitro-4-(difluoromethoxy)-5-methoxybenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-(Difluoromethoxy)-5-Methoxy-2-Nitrobenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.