Description

Ethyl 2-Cyano-2-(5-(Trifluoromethyl)Pyridin-2-Yl)Acetate is a high-value, multi-functional chemical intermediate featuring a pyridine core substituted with a trifluoromethyl group and a cyanoacetate ester moiety. This compound is critical for its role in synthesizing advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where the trifluoromethyl group imparts desirable metabolic stability and lipophilicity. It is primarily sought by R&D chemists and process development scientists working on novel active ingredients, including kinase inhibitors and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the bioactivity of the trifluoromethylpyridine structure.
• Material Science Research: Serves as a precursor for functionalized ligands or monomers in the development of specialty polymers and advanced materials.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical and CDMO (Contract Development and Manufacturing Organization) services producing bespoke compounds for clients.

Basic Information

Product Name	Ethyl 2-Cyano-2-(5-(Trifluoromethyl)Pyridin-2-Yl)Acetate
CAS No.	923148-75-8
Molecular Formula	C11H9F3N2O2
Molecular Weight	258.20 g/mol
Synonyms	Ethyl (5-(trifluoromethyl)pyridin-2-yl)cyanoacetate; 2-Cyano-2-(5-(trifluoromethyl)-2-pyridinyl)acetic acid ethyl ester; Ethyl α-cyano-α-(5-(trifluoromethyl)pyridin-2-yl)acetate; Acetic acid, 2-cyano-2-[5-(trifluoromethyl)-2-pyridinyl]-, ethyl ester; 923148-75-8; (5-Trifluoromethyl-pyridin-2-yl)-cyano-acetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-Cyano-2-(5-(Trifluoromethyl)Pyridin-2-Yl)Acetate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Quality is verified through advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. Due to its light-sensitive nature, containers should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.