Description

Dimethyl 2-(6-Chloronicotinoyl) Malonate is a high-purity, advanced pharmaceutical intermediate characterized by its chloronicotinoyl and malonate ester functional groups. This compound is essential for the synthesis of complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing heterocyclic scaffolds and facilitating key carbon-carbon bond-forming reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing nicotinamide or pyridine-based pharmacophores.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its chloronicotinoyl moiety for biological activity.
• Chemical Research & Development: Serves as a versatile reagent for organic synthesis, enabling reactions such as Knoevenagel condensations and cyclizations to form heterocyclic compounds.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and functional materials requiring specific chlorinated pyridine structures.
• Academic Research: Utilized in university and institutional labs for methodological studies in synthetic organic chemistry and catalysis.

Basic Information

Product Name	Dimethyl 2-(6-Chloronicotinoyl) Malonate
CAS No.	923034-23-5
Molecular Formula	C12H10ClNO5
Molecular Weight	283.66 g/mol
Synonyms	Dimethyl (6-chloropyridine-3-carbonyl)propanedioate; Propanedioic acid, 2-[(6-chloro-3-pyridinyl)carbonyl]-, 1,3-dimethyl ester; 2-(6-Chloronicotinoyl)malonic Acid Dimethyl Ester; Dimethyl (6-chloronicotinoyl)malonate; 1,3-Dimethyl 2-(6-chloronicotinoyl)malonate; (6-Chloronicotinoyl)malonic Acid Dimethyl Ester; DMCM
EINECS	Contact for details

Quality Control

Our Dimethyl 2-(6-Chloronicotinoyl) Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.