Description

2-Chloro-3-Fluoro-4-Carboxypyridine is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique halogenated pyridine core with a carboxylic acid group makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in transition metal catalysis and organocatalysis, enabling more efficient chemical transformations.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its modifiable carboxylic acid group.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-3-Fluoro-4-Carboxypyridine
CAS No.	922147-45-3
Molecular Formula	C7H3ClFNO2
Molecular Weight	175.56 g/mol
Synonyms	4-Pyridinecarboxylic acid, 2-chloro-3-fluoro-; 2-Chloro-3-fluoropyridine-4-carboxylic acid; 3-Fluoro-2-chloroisonicotinic acid; 2-Chloro-3-fluoro-4-pyridinecarboxylic acid; 4-Carboxy-2-chloro-3-fluoropyridine; 2-Chloro-3-fluoroisonicotinic acid; 922147-45-3
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoro-4-Carboxypyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.