Description

Pentafluorophenyl 4-Methyl-3,4-Dihydro-2H-Pyrido[3,2-B][1,4]Oxazine-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure and pentafluorophenyl ester group. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers focused on developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the final stages or key coupling reactions for constructing novel active pharmaceutical ingredients with enhanced bioavailability or receptor binding affinity.
• Bioconjugation & Probe Development: The reactive pentafluorophenyl ester group facilitates efficient conjugation reactions for creating chemical probes, labeled compounds, or antibody-drug conjugates (ADCs).
• Academic & Institutional Research: Utilized in universities and research institutes for investigating new synthetic methodologies and heterocyclic chemistry.
• Custom Synthesis & Scale-Up: A key material for fine chemical companies offering custom synthesis services from milligram to kilogram scale for client projects.

Basic Information

Product Name	Pentafluorophenyl 4-Methyl-3,4-Dihydro-2H-Pyrido[3,2-B][1,4]Oxazine-7-Carboxylate
CAS No.	921938-83-2
Molecular Formula	C19H12F5NO3
Molecular Weight	397.30 g/mol
Synonyms	4-Methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-carboxylic acid pentafluorophenyl ester; Pentafluorophenyl 4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-carboxylate; 2H-Pyrido[3,2-b][1,4]oxazine-7-carboxylic acid, 3,4-dihydro-4-methyl-, 2,3,4,5,6-pentafluorophenyl ester; PFP ester of 4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-carboxylic acid; CAS 921938-83-2
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 4-Methyl-3,4-Dihydro-2H-Pyrido[3,2-B][1,4]Oxazine-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep the container sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.