Description

3-Amino-2-Iodo-6-(Trifluoromethyl)-Pyridine is a highly functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique combination of amino, iodo, and trifluoromethyl substituents makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a scaffold for designing novel ligands in transition metal catalysis and organocatalysis due to its electron-deficient pyridine core and halogen handle.
• Material Science Research: Building block for organic electronic materials, such as non-linear optical (NLO) materials and charge-transport layers, leveraging its electron-withdrawing substituents.
• Cross-Coupling Reactions: The iodine atom provides an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create biaryl and other complex structures.
• Fluorine Chemistry: Valuable synthon for introducing the pharmacologically advantageous trifluoromethyl group into target molecules via further functionalization.

Basic Information

Product Name	3-Amino-2-Iodo-6-(Trifluoromethyl)-Pyridine
CAS No.	920979-04-0
Molecular Formula	C6H4F3IN2
Molecular Weight	288.01 g/mol
Synonyms	2-Iodo-3-amino-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-3-pyridinamine, 2-iodo-; 3-Amino-2-iodo-6-trifluoromethylpyridine; 2-Iodo-6-trifluoromethylpyridin-3-amine; 3-Pyridinamine, 2-iodo-6-(trifluoromethyl)-; 920979-04-0; AI3-52075
EINECS	Contact for details

Quality Control

Our 3-Amino-2-Iodo-6-(Trifluoromethyl)-Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing all critical quality parameters. Our quality commitment supports applications in GMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.