Description

Ethyl 5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate is a high-purity fluorinated pyrrolopyridine derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of novel, targeted therapeutic agents, particularly in oncology and antiviral research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up API (Active Pharmaceutical Ingredient) manufacturing processes.
• Bioconjugation & Probe Synthesis: The ester moiety allows for further functionalization, useful in creating chemical probes for biological target identification.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and early-stage drug development.

Basic Information

Product Name	Ethyl 5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate
CAS No.	920978-95-6
Molecular Formula	C10H9FN2O2
Molecular Weight	208.19 g/mol
Synonyms	5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester; Ethyl 5-fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-fluoro-, ethyl ester; 920978-95-6; 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester; 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylate ethyl ester; Ethyl 5-fluoro-1H-7-azaindole-2-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.