Description

4-Chloro-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique fused pyrrolopyridine scaffold, which serves as a privileged structure for modulating biological activity and material properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient π-system.
• Chemical Biology: Employed as a molecular probe or a tag in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	4-Chloro-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile
CAS No.	920966-02-5
Molecular Formula	C8H4ClN3
Molecular Weight	177.59 g/mol
Synonyms	4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; 4-Chloro-5-cyano-1H-pyrrolo[2,3-b]pyridine; 5-Cyano-4-chloro-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-; 920966-02-5; 4-Chloro-1H-7-azaindole-5-carbonitrile; 4-Chloro-5-cyano-7-azaindole
EINECS	Contact for details

Quality Control

Our 4-Chloro-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and MS confirmation. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Production can be aligned with research-grade or cGMP standards based on customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.