Description

2-Chloro-4-Isocyano-1-Methoxybenzene is a versatile aromatic isocyanide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the construction of complex heterocyclic scaffolds and functional materials, enabling efficient multi-component reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in multi-component reactions (MCRs) like the Ugi and Passerini reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the reactivity of the isocyano group.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, coordination polymers, and metal-organic frameworks (MOFs).
• Ligand Synthesis: Employed for the preparation of novel isocyanide-based ligands for catalysis and organometallic chemistry.
• Chemical Biology Probes: Utilized in the creation of activity-based probes and bio-conjugation reagents due to its selective reactivity.
• Dye and Pigment Intermediate: Acts as a precursor in the synthesis of complex organic dyes and functional pigments.

Basic Information

Product Name	2-Chloro-4-Isocyano-1-Methoxybenzene
CAS No.	920524-21-6
Molecular Formula	C8H6ClNO
Molecular Weight	167.59 g/mol
Synonyms	1-Chloro-2-Isocyano-4-Methoxybenzene; 4-Isocyano-2-Chloroanisole; 2-Chloro-4-Isocyanoanisole; 2-Chloro-4-Methoxyphenyl Isocyanide; 2-Chloro-4-Methoxybenzenisocyanide; 2-Chloro-4-Methoxyphenyl Isonitrile; 2-Chloroanisole-4-isocyanide
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Isocyano-1-Methoxybenzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.