Description

tert-Butyl 3-oxospiro[isoindoline-1,4'-piperidine]-1'-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought after by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in the development of innovative therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Used in the construction of core scaffolds for potential kinase inhibitors in oncology research.
• Medicinal Chemistry & Lead Optimization: Enables structure-activity relationship (SAR) studies and the exploration of novel chemical space in drug discovery programs.
• Custom Synthesis & Scale-Up: Supplied for process development, from milligram-scale research to kilogram-scale cGMP manufacturing for clinical trials.
• Academic Research: Utilized in university and institutional labs for studying spirocyclic compound chemistry and biological activity.

Basic Information

Product Name	tert-Butyl 3-oxospiro[isoindoline-1,4'-piperidine]-1'-carboxylate
CAS No.	920023-54-7
Molecular Formula	C17H22N2O3
Molecular Weight	302.37 g/mol
Synonyms	1'-Boc-3-oxospiro[isoindoline-1,4'-piperidine]; tert-Butyl 3-oxo-1,4-dihydrospiro[isoindole-1,4'-piperidine]-1'-carboxylate; 1,1-Dimethylethyl 3-oxo-1,4-dihydrospiro[isoindole-1,4'-piperidine]-1'-carboxylate; 3-Oxospiro[isoindoline-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[isoindoline-1,4'-piperidine]-1'-carboxylic acid, 3-oxo-, 1,1-dimethylethyl ester; Boc-protected 3-oxospiro[isoindoline-1,4'-piperidine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-oxospiro[isoindoline-1,4'-piperidine]-1'-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.