Description

Pyrido[3,2-F]-1,4-Oxazepin-5(2H)-One, 8-Chloro-7-Fluoro-3,4-Dihydro-4-Methyl- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This heterocyclic compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the production of sophisticated drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development and commercial-scale manufacturing of new chemical entities (NCEs) and proprietary drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new bioactive molecules.
• API Synthesis: Serves as a core scaffold or fragment in multi-step syntheses of complex target molecules for pre-clinical and clinical trials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for advanced studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Pyrido[3,2-F]-1,4-Oxazepin-5(2H)-One, 8-Chloro-7-Fluoro-3,4-Dihydro-4-Methyl-
CAS No.	919788-60-6
Molecular Formula	C11H8ClFN2O2
Molecular Weight	254.64 g/mol
Synonyms	8-Chloro-7-fluoro-3,4-dihydro-4-methylpyrido[3,2-f][1,4]oxazepin-5(2H)-one; 8-Chloro-7-fluoro-4-methyl-2,3-dihydro-5H-pyrido[3,2-f][1,4]oxazepin-5-one; 919788-60-6; 8-Chloro-7-fluoro-4-methyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-5-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical development. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.