Description

2-Chloro-5-[4-(Trifluoromethoxy)Phenyl]-Pyridine is a high-value halogenated pyridine derivative, recognized for its unique trifluoromethoxy-substituted aromatic structure. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern synthetic chemistry. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, leveraging the trifluoromethoxy group for enhanced biological activity and stability.
• Material Science Research: Acts as a precursor for the synthesis of functionalized ligands and organic electronic materials.
• Cross-Coupling Reactions: Serves as a valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for biochemical and pharmacological studies.

Basic Information

Product Name	2-Chloro-5-[4-(Trifluoromethoxy)Phenyl]-Pyridine
CAS No.	919478-28-7
Molecular Formula	C12H7ClF3NO
Molecular Weight	273.64 g/mol
Synonyms	2-Chloro-5-(4-(trifluoromethoxy)phenyl)pyridine; 5-(4-Trifluoromethoxyphenyl)-2-chloropyridine; 2-Chloro-5-(4-trifluoromethoxyphenyl)pyridine; 919478-28-7; Pyridine, 2-chloro-5-[4-(trifluoromethoxy)phenyl]-; 2-Chloro-5-(p-(trifluoromethoxy)phenyl)pyridine
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-5-[4-(Trifluoromethoxy)Phenyl]-Pyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. All materials are characterized by advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.