Description

4-(3-Hydroxy-1-Methylpropyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, especially in neurological and psychiatric drug discovery.
• API Synthesis: Used as a building block for constructing the piperidine moiety in final Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug development programs.
• Process Chemistry: Employed in scale-up and process development for the commercial manufacturing of target drug substances.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-(3-Hydroxy-1-Methylpropyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	919360-49-9
Molecular Formula	C14H27NO3
Molecular Weight	257.37 g/mol
Synonyms	tert-Butyl 4-(3-hydroxy-1-methylpropyl)piperidine-1-carboxylate; 1-Boc-4-(3-hydroxy-1-methylpropyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(3-hydroxy-1-methylpropyl)piperidine; 4-(3-Hydroxy-1-methylpropyl)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(3-hydroxy-1-methylpropyl)piperidine; 919360-49-9; BOC-4-(3-Hydroxy-1-methylpropyl)piperidine
EINECS	Contact for details

Quality Control

Our 4-(3-Hydroxy-1-Methylpropyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.