Description

n-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Propan-2-Amine is a high-value, functionalized pyridine-boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in the combination of a protected boronic acid group and a secondary amine functionality, enabling versatile cross-coupling and derivatization reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular scaffolds for drug discovery, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyridine-based architectures.
• Ligand and Catalyst Development: The amine and boronate ester groups make it a versatile starting material for synthesizing chelating ligands and organocatalysts.
• Material Science: Employed in the synthesis of organic semiconductors, metal-organic frameworks (MOFs), and other functional organic materials.
• Chemical Biology & Proteomics: Acts as a molecular probe or a handle for bioconjugation strategies due to its reactive functional groups.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research programs.

Basic Information

Product Name	n-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Propan-2-Amine
CAS No.	919347-30-1
Molecular Formula	C15H25BN2O2
Molecular Weight	276.19 g/mol
Synonyms	1-[(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methyl]propan-2-amine; 2-Amino-2-methylpropyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ylmethyl ether (incorrect but common misnomer); 3-((Isopropylamino)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; N-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ylmethanamine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-((isopropylamino)methyl)pyridine; PINAP boronate derivative; Pyridine-3-boronic acid pinacol ester, 5-((isopropylamino)methyl)-
EINECS	Contact for details

Quality Control

Our n-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Propan-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.