Description

3-Pyridinemethanamine, n-(Cyclopropylmethyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative featuring a pyridine core. This compound is a critical advanced pharmaceutical intermediate (API) designed for use in modern synthetic methodologies, particularly Suzuki-Miyaura cross-coupling reactions. It is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require precise molecular building blocks for constructing complex heterocyclic compounds. The product is supplied to meet the stringent purity and consistency demands of process chemistry and scale-up manufacturing.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a precursor for creating functionalized polymers, ligands for catalysis, and organic electronic materials.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura coupling to form biaryl and heterobiaryl structures, a cornerstone reaction in medicinal chemistry.
• Chemical Biology & Proteomics: Can be employed in the synthesis of molecular probes and tags for studying biological systems.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis facilities for client-directed projects.

Basic Information

Product Name	3-Pyridinemethanamine, n-(Cyclopropylmethyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	919347-13-0
Molecular Formula	C16H25BN2O2
Molecular Weight	288.20 g/mol
Synonyms	N-[(Cyclopropylmethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]methanamine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(cyclopropylmethyl)pyridin-3-ylmethanamine; 3-((Cyclopropylmethylamino)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (5-((Cyclopropylmethylamino)methyl)pyridin-3-yl)boronic acid pinacol ester; Pinacol [5-((cyclopropylmethylamino)methyl)pyridin-3-yl]boronate; Boronic ester intermediate 919347-13-0
EINECS	Contact for details

Quality Control

Our production of this high-purity boronic ester adheres to strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity, purity, and stability. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or manufacturing specifications. Our quality system is designed to support cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage to maintain optimal purity and reactivity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.