Description

1,8-Diazaspiro[5.5]Undecane-8-Carboxylic Acid, 1-(2,2,2-Trifluoroacetyl)-, 1,1-Dimethylethyl Ester is a sophisticated spirocyclic building block and protected intermediate of significant value in advanced organic synthesis. Its core structure is designed to provide rigidity and specific stereoelectronic properties, making it a critical component for constructing complex molecular architectures. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas requiring constrained, nitrogen-containing heterocycles.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its spirocyclic scaffold can contribute to unique biological activity and improved environmental profiles.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized chelating ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Synthesis: Employed to build molecular tools for studying biological pathways and protein functions.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific thermal or mechanical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic projects.

Basic Information

Product Name	1,8-Diazaspiro[5.5]Undecane-8-Carboxylic Acid, 1-(2,2,2-Trifluoroacetyl)-, 1,1-Dimethylethyl Ester
CAS No.	918896-29-4
Molecular Formula	C15H23F3N2O3
Molecular Weight	336.35 g/mol
Synonyms	tert-Butyl 1-(2,2,2-trifluoroacetyl)-1,8-diazaspiro[5.5]undecane-8-carboxylate; 1,8-Diazaspiro[5.5]undecane-8-carboxylic acid, 1-(trifluoroacetyl)-, 1,1-dimethylethyl ester; 1-(2,2,2-Trifluoroacetyl)-1,8-diazaspiro[5.5]undecane-8-carboxylic acid tert-butyl ester; 1,8-Diazaspiro[5.5]undecane-8-carboxylate, 1-(trifluoroacetyl)-, tert-butyl ester; N-Boc-1-(trifluoroacetyl)-1,8-diazaspiro[5.5]undecane (common abbreviation); 1-(Trifluoroacetyl)-1,8-diazaspiro[5.5]undecane-8-carboxylic acid tert-butyl ester; 1,8-Diazaspiro[5.5]undecane, 8-[(1,1-dimethylethoxy)carbonyl]-1-[(trifluoroacetyl)amino]- (alternative indexing)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.