Description

A-Tosyl-(4-Chlorobenzyl) Isocyanide is a specialized organic building block featuring both an isocyanide functional group and a tosyl-protected chlorobenzyl moiety. This compound is highly valued in modern synthetic chemistry for its versatility as a key reactant in multicomponent reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in drug discovery, catalyst development, and the synthesis of functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in the construction of nitrogen-containing heterocycles via Ugi and Passerini-type multicomponent reactions.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its reactivity to create diverse molecular architectures.
• Chemical Biology & Probe Development: Employed in the synthesis of activity-based probes and molecular tags for studying biological systems and enzyme functions.
• Material Science: Serves as a monomer or precursor in the synthesis of functional polymers and advanced organic materials with tailored properties.
• Catalyst Ligand Synthesis: Utilized as a precursor for creating novel isocyanide-based ligands used in transition metal catalysis.
• Combinatorial Chemistry: A valuable reagent in library synthesis for high-throughput screening in drug discovery programs.

Basic Information

Product Name	A-Tosyl-(4-Chlorobenzyl) Isocyanide
CAS No.	918892-30-5
Molecular Formula	C15H12ClNO2S
Molecular Weight	305.78 g/mol
Synonyms	4-Methyl-N-[(4-chlorophenyl)methyl]-N-(isocyanomethyl)benzenesulfonamide; 1-[(4-Chlorophenyl)methyl]-1-isocyano-4-methylsulfonylbenzene; p-Toluenesulfonyl(4-chlorobenzyl) isocyanide; Tosyl(4-chlorobenzyl) isocyanide; (4-Chlorobenzyl)(tosylmethyl) isocyanide; TOSMIC-(4-Cl-Bn); 4-Chlorobenzyl isocyanide p-toluenesulfonyl derivative
EINECS	Contact for details

Quality Control

Our A-Tosyl-(4-Chlorobenzyl) Isocyanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability, as the isocyanide functional group can be sensitive to moisture and oxidation over prolonged periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.