Description

1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]-3-Iodo- is a high-value, protected heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a versatile and reactive iodine handle for cross-coupling reactions, enabling the precise construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients and functional molecules, leveraging its role in Suzuki, Stille, and other palladium-catalyzed transformations.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in creating new active ingredients for crop protection with specific modes of action.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs and semiconductors.
• Cross-Coupling Reactions: The iodine atom is a prime site for Suzuki-Miyaura, Stille, and Sonogashira couplings to introduce complex aryl, alkenyl, or alkynyl groups.
• Chemical Biology & Proteomics: Useful for synthesizing tagged molecules or probes for studying biological systems.
• Ligand & Catalyst Development: Acts as a scaffold for creating novel ligands used in asymmetric catalysis.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]-3-Iodo-
CAS No.	918524-22-8
Molecular Formula	C13H19IN2Si
Molecular Weight	374.30 g/mol
Synonyms	3-Iodo-1-[(tert-butyldimethylsilyl)]-1H-pyrrolo[2,3-b]pyridine; 1-(tert-Butyldimethylsilyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine; 1-(Tert-Butyldimethylsilyl)-3-iodo-7-azaindole; 3-Iodo-1-((tert-butyldimethylsilyl))-7-azaindole; 1-TBDMS-3-iodo-7-azaindole; 3-Iodo-1H-pyrrolo[2,3-b]pyridine, 1-[(1,1-dimethylethyl)dimethylsilyl]-; 7-Azaindole, 1-(tert-butyldimethylsilyl)-3-iodo-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]-3-Iodo- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.