Description

1H-Pyrrolo[2,3-B]Pyridine-5-Methanol, A,A-Dimethyl-1-[Tris(1-Methylethyl)Silyl]- is a high-value, organosilicon-protected heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it provides a strategically functionalized and protected pyrrolopyridine core, enabling the efficient construction of complex molecular architectures with precise stereochemical control. Pharmaceutical and agrochemical research organizations need this specialized intermediate for developing novel active ingredients, particularly in kinase inhibitor and other small-molecule therapeutic programs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of kinase inhibitors, anticancer agents, and other biologically active small molecules.
• Agrochemical Synthesis: Used in creating novel active ingredients for crop protection with enhanced efficacy and selectivity.
• Material Science Research: Serves as a precursor for functional organic materials, including ligands for catalysis and components for organic electronics.
• Academic & Contract Research: Employed in methodological studies and complex multi-step synthesis projects within university and CRO laboratories.
• Process Chemistry Development: Utilized for scaling up synthetic routes from milligram to kilogram scale under GMP or non-GMP conditions.
• Custom Synthesis Building Block: Provides a versatile starting point for custom synthesis services targeting specific client molecular targets.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Methanol, A,A-Dimethyl-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	918523-63-4
Molecular Formula	C19H32N2OSi
Molecular Weight	332.56 g/mol
Synonyms	5-(Hydroxymethyl)-1-(triisopropylsilyl)-7-azaindole; 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-methanol; 1-TIPS-7-azaindole-5-methanol; 1-Triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine-5-methanol; 5-(Hydroxymethyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 7-Azaindole-5-methanol; 1-TIPS-5-(hydroxymethyl)-7-azaindole; 7-Azaindole-5-methanol, 1-(triisopropylsilyl)-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-5-Methanol, A,A-Dimethyl-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with stringent specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry inert atmosphere to protect the moisture-sensitive silyl protecting group. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.