Description

5-Chloro-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine core. This compound is critical for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in the discovery of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new molecules with improved efficacy and safety profiles.
• Protecting Group Strategy: The triisopropylsilyl (TIPS) group protects the pyrrole nitrogen, allowing for selective functionalization at other positions on the heterocyclic scaffold during synthesis.
• API Development: Integral to the development pathway of potential new drugs in oncology, neurology, and inflammatory diseases.
• Chemical Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery campaigns.
• Process Chemistry: Serves as a defined starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.

Basic Information

Product Name	5-Chloro-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	918523-59-8
Molecular Formula	C17H27ClN2Si
Molecular Weight	322.95 g/mol
Synonyms	5-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-1-(triisopropylsilyl)-; 5-Chloro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-1-TIPS-1H-pyrrolo[2,3-b]pyridine; TIPS-5-Chloropyrrolopyridine; 918523-59-8; 5-Chloro-1-(triisopropylsilyl)-7-azaindole
EINECS	Contact for details

Quality Control

Our 5-Chloro-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support development work that may transition to cGMP production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.