Description

2-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique pyrrolopyridine core, functionalized with a trifluoromethyl group, imparts desirable properties such as enhanced metabolic stability and lipophilicity, which are critical for developing novel bioactive molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key scaffold in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science Precursor: Acts as a building block for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space for drug discovery programs.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and complex molecules at various scales.

Basic Information

Product Name	2-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	918514-78-0
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	2-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 2-(trifluoromethyl)-; 2-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; 2-Trifluoromethyl-7-azaindole; 7-Azaindole, 2-trifluoromethyl-; 2-(Trifluoromethyl)-7-azaindole; 2-CF3-1H-pyrrolo[2,3-b]pyridine; 2-CF3-7-azaindole
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.