Description

1-Propanesulfonamide, n-[3-[(5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Carbonyl]-2,4-Difluorophenyl]- is a high-purity, advanced pharmaceutical intermediate designed for precision synthesis. This compound is critical for research and development in targeted drug discovery programs, particularly in oncology and kinase inhibitor development. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and contract research organizations (CROs) requiring structurally complex building blocks for novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and targeted cancer therapies.
• Biochemical Research: Used as a reference standard or probe molecule in enzymatic and cellular assay development.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical Development: Employed in the production of compounds for pharmacological and toxicological evaluation.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of investigational new drugs (INDs).
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic and sulfonamide chemistry.

Basic Information

Product Name	1-Propanesulfonamide, n-[3-[(5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Carbonyl]-2,4-Difluorophenyl]-
CAS No.	918504-27-5
Molecular Formula	C₁₇H₁₂BrF₂N₃O₃S
Molecular Weight	456.26 g/mol
Synonyms	N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; 5-Bromo-N-(2,4-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-3-amine; 918504-27-5; 1-Propanesulfonamide, N-[3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-; 5-Bromo-3-[(2,4-difluoro-3-(propylsulfonamido)benzoyl)]-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-Propanesulfonamide, n-[3-[(5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Carbonyl]-2,4-Difluorophenyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.