Description

3-Methyl-2-(Methylthio)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyridine is a high-purity, advanced pharmaceutical intermediate and versatile organoboron building block. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Suzuki-Miyaura Cross-Coupling: Essential boron reagent for forming carbon-carbon bonds between pyridine derivatives and aryl/heteroaryl halides under palladium catalysis.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides requiring specific pyridine-based scaffolds.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the synthesis of bifunctional molecules for targeted protein degradation research.
• Ligand Synthesis for Catalysis: Building block for constructing novel pyridine-containing ligands used in homogeneous catalysis.

Basic Information

Item	Detail
Product Name	3-Methyl-2-(Methylthio)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyridine
CAS No.	918350-15-9
Molecular Formula	C14H22BNO2S
Molecular Weight	279.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-2-(methylthio)pyridine; 2-Methylthio-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylpyridine; 3-Methyl-2-(methylsulfanyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pyridine, 3-methyl-2-(methylthio)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 918350-15-9; Boronic acid, B-[3-methyl-2-(methylthio)-5-pyridinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; B-[3-Methyl-2-(methylthio)-5-pyridinyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Methyl-2-(Methylthio)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.