Description

4-Bromo-2-Fluoro-3-Iodopyridine is a highly functionalized halogenated pyridine derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique substitution pattern offers distinct reactivity for selective cross-coupling and nucleophilic substitution reactions, enabling the efficient construction of complex heterocyclic architectures. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen sites for introducing specific bioactive moieties.
• Material Science Building Block: Employed in the creation of functionalized ligands for catalysis, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki-Miyaura, Stille, and Negishi couplings due to the presence of bromine and iodine, allowing for sequential functionalization.
• Nucleophilic Aromatic Substitution: The fluorine atom at the 2-position is highly activated for displacement by various nucleophiles, enabling rapid diversification of the pyridine core.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Item	Detail
Product Name	4-Bromo-2-Fluoro-3-Iodopyridine
CAS No.	917969-51-8
Molecular Formula	C5H2BrFIN
Molecular Weight	301.88 g/mol
Synonyms	4-Bromo-2-fluoro-3-iodopyridine; 3-Iodo-4-bromo-2-fluoropyridine; 2-Fluoro-4-bromo-3-iodopyridine; Pyridine, 4-bromo-2-fluoro-3-iodo-; 917969-51-8; 4-Br-2-F-3-I-pyridine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-3-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent lot-to-lot performance. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, handling and packaging are performed under amber glass or light-protective conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.