Description

5-Nitro-2-(2,2,2-trifluoro-1-trifluoromethylethoxy)pyridine is a high-value, fluorinated pyridine derivative, distinguished by its unique trifluoromethoxy and nitro substituents. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry, enabling the introduction of fluorine atoms to enhance the metabolic stability and bioavailability of target molecules. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel agrochemicals, specialty materials, and active pharmaceutical ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Serves as a precursor for developing new-generation herbicides and pesticides with improved efficacy and environmental profile.
• Material Science: Used in the research and production of specialty polymers, liquid crystals, and electronic chemicals where fluorination imparts desired properties like chemical resistance and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and reduction reactions to construct complex fluorinated heterocycles.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in regulatory and research laboratories.

Basic Information

Product Name	5-Nitro-2-(2,2,2-trifluoro-1-trifluoromethylethoxy)pyridine
CAS No.	917924-00-6
Molecular Formula	C9H4F6N2O3
Molecular Weight	302.13 g/mol
Synonyms	2-(1,1,1,3,3,3-Hexafluoro-2-propoxy)-5-nitropyridine; 5-Nitro-2-[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]pyridine; 5-Nitro-2-(hexafluoroisopropoxy)pyridine; 2-(Hexafluoroisopropoxy)-5-nitropyridine; Pyridine, 2-[(1,1,1,3,3,3-hexafluoro-2-propyl)oxy]-5-nitro-; 917924-00-6
EINECS	Contact for details

Quality Control

Our production of 5-Nitro-2-(2,2,2-trifluoro-1-trifluoromethylethoxy)pyridine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality system is designed to support cGMP requirements for pharmaceutical applications, ensuring traceability and documentation excellence.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of nitro and fluorinated groups, it should be stored separately from strong reducing agents, strong bases, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.