Description

2-Bromo-5-Fluoro-3-Nitro-4-Picoline is a high-value, multi-functional heterocyclic building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, due to its unique halogen and nitro substitution pattern. It is primarily sought after by research chemists and process development scientists for creating novel active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a building block for advanced organic electronic materials and liquid crystals.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex pyridine-based motifs.
• Academic & Contract Research: Essential for medicinal chemistry programs and discovery research in academic and CRO (Contract Research Organization) settings.

Basic Information

Item	Details
Product Name	2-Bromo-5-Fluoro-3-Nitro-4-Picoline
CAS No.	917918-84-4
Molecular Formula	C6H4BrFN2O2
Molecular Weight	235.01 g/mol
Synonyms	4-Picoline, 2-bromo-5-fluoro-3-nitro-; 2-Bromo-5-fluoro-3-nitropyridine, 4-methyl-; 3-Nitro-2-bromo-5-fluoro-4-methylpyridine; 4-Methyl-2-bromo-5-fluoro-3-nitropyridine; 2-Bromo-5-fluoro-3-nitro-4-methylpyridine; 5-Fluoro-2-bromo-3-nitro-4-picoline
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoro-3-Nitro-4-Picoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.