Description

1-Boc-4-[(4-Fluorophenyl)Methyl]-4-(Hydroxymethyl)-Piperidine is a high-purity, protected piperidine derivative that serves as a critical building block in modern synthetic organic chemistry. Its value lies in its dual functionality, offering both a Boc-protected amine and a hydroxymethyl group for further synthetic elaboration, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used as a precursor in the development of advanced pesticides and herbicides, leveraging the fluorophenyl moiety for bioactivity.
• Peptidomimetic Chemistry: Serves as a constrained scaffold or a building block for creating peptide mimics with enhanced metabolic stability.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under GMP or ISO guidelines.
• Academic & R&D: Used in university and institutional laboratories for methodological development and exploring new chemical spaces.

Basic Information

Product Name	1-Boc-4-[(4-Fluorophenyl)Methyl]-4-(Hydroxymethyl)-Piperidine
CAS No.	917755-78-3
Molecular Formula	C18H26FNO3
Molecular Weight	323.41 g/mol
Synonyms	tert-Butyl 4-[(4-fluorophenyl)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(4-fluorobenzyl)]-4-(hydroxymethyl)piperidine; 4-[(4-Fluorophenyl)methyl]-4-(hydroxymethyl)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(4-Fluorobenzyl)-4-hydroxymethylpiperidine; 1-Boc-4-(4-Fluorobenzyl)-4-piperidinemethanol; BOC-Pip(4-CH2OH,4-4F-Bn)-OH
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[(4-Fluorophenyl)Methyl]-4-(Hydroxymethyl)-Piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.