Description

n-T-Butylglycine tert-Butyl Ester is a high-purity, non-natural amino acid derivative featuring a sterically hindered tert-butyl protecting group on both the amine and carboxylic acid functionalities. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and solubility in organic solvents. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers for developing novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used to introduce steric bulk and metabolic stability into peptide backbones for creating drug candidates with improved pharmacokinetic profiles.
• Protease Inhibitor Development: Serves as a crucial component in the structure of inhibitors targeting various proteolytic enzymes.
• Chemical Biology & Research: Employed in the study of protein-protein interactions and the design of novel biochemical probes.
• Custom Peptide Synthesis: A valuable building block for contract research organizations (CROs) and CDMOs producing custom, non-standard amino acid sequences.
• Agrochemical Research: Potential application in the synthesis of bioactive compounds for crop protection.

Basic Information

Product Name	n-T-Butylglycine tert-Butyl Ester
CAS No.	916885-51-3
Molecular Formula	C10H21NO2
Molecular Weight	187.28 g/mol
Synonyms	2-(tert-Butylamino)acetic acid tert-butyl ester; tert-Butyl 2-(tert-butylamino)acetate; N-(tert-Butyl)glycine tert-butyl ester; (tert-Butoxycarbonylmethyl)(tert-butyl)amine; Boc-NH-CH2-COOtBu (common abbreviation); Glycine, N-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-T-Butylglycine tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/NMR), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.