Description

3-Hydroxy-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-3'-Carbonitrile, 98+% is a high-purity, advanced pharmaceutical intermediate characterized by its unique bicyclic structure incorporating a nitrile and a hydroxyl group. This compound is of significant value for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Ligand Synthesis: Employed in the development of novel ligands for biological targets, including enzymes and G-protein-coupled receptors (GPCRs).
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Academic Research: Serves as a starting material for synthetic methodology development and novel heterocyclic chemistry in university laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	3-Hydroxy-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-3'-Carbonitrile
CAS No.	916791-18-9
Molecular Formula	C11H13N3O
Molecular Weight	203.04 g/mol
Synonyms	3-Hydroxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile; 3'-Cyano-3-hydroxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl; 3-Hydroxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-carbonitrile; 916791-18-9; 3-Hydroxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile (9CI); 3-Hydroxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-carbonitrile (8CI)
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3,4,5,6-Tetrahydro-2H-[1,2']Bipyridinyl-3'-Carbonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the specified 98+% purity grade. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.