Description

1H-Pyrrolo[2,3-B]Pyridine, 2-Iodo-4-Methoxy-1-(Phenylsulfonyl)- is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its unique molecular architecture, which incorporates a halogenated pyrrolopyridine core protected by a phenylsulfonyl group, making it a versatile intermediate for constructing complex nitrogen-containing scaffolds. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors, receptor antagonists, and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used to build complex heterocyclic structures for the development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to introduce complex substituents.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship (SAR) exploration by allowing systematic modification of the pyrrolopyridine core.
• Chemical Biology Probes: Used to synthesize labeled compounds or probes for studying biological pathways and target engagement.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 2-Iodo-4-Methoxy-1-(Phenylsulfonyl)-
CAS No.	916574-88-4
Molecular Formula	C14H11IN2O3S
Molecular Weight	414.21 g/mol
Synonyms	2-Iodo-4-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Benzenesulfonyl)-2-iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine; 2-Iodo-4-methoxy-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common name variant); 1H-Pyrrolo[2,3-b]pyridine, 2-iodo-4-methoxy-1-(phenylsulfonyl)-; 916574-88-4; 2-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine 1-sulfonate
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 2-Iodo-4-Methoxy-1-(Phenylsulfonyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.