Description

Benzyl 3-Cyano-4-oxopiperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine-based scaffold with cyano and carboxylate functional groups. This compound is of significant value for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical producers engaged in developing novel therapeutics, including kinase inhibitors and other targeted small molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Used in the construction of piperidine-based cores found in various classes of kinase inhibitors for oncology and inflammatory diseases.
• Custom Synthesis & Scale-Up: Employed by CROs and CDMOs for process development, from milligram-scale research to kilogram-scale cGMP production.
• Academic & Industrial R&D: Utilized in academic laboratories and industrial R&D departments for exploring new chemical entities and novel synthetic pathways.

Basic Information

Product Name	Benzyl 3-Cyano-4-oxopiperidine-1-carboxylate
CAS No.	916423-53-5
Molecular Formula	C14H14N2O3
Molecular Weight	258.27 g/mol
Synonyms	1-(Benzyloxycarbonyl)-3-cyano-4-oxopiperidine; 3-Cyano-1-[(phenylmethoxy)carbonyl]-4-piperidinone; 4-Oxo-3-cyano-1-piperidinecarboxylic acid phenylmethyl ester; Benzyl 3-cyano-4-oxo-1-piperidinecarboxylate; 1-CBz-3-cyano-4-piperidinone; 3-Cyano-1-CBz-4-piperidinone; 1-N-CBz-3-cyano-4-piperidinone; 4-Oxopiperidine-1,3-dicarboxylic acid 1-benzyl ester 3-nitrile
EINECS	Contact for details

Quality Control

Our Benzyl 3-Cyano-4-oxopiperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for pharmaceutical intermediates in research and development supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.