Description

5-Bromo-1-Methyl-1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This heterocyclic carboxylic acid derivative serves as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of chemical probes to study biological pathways and protein functions.
• Agrochemical Research: Serves as a building block for developing novel crop protection agents and pesticides.
• Contract Manufacturing (CMO/CDMO): Supplied to contract manufacturing organizations for custom synthesis and scale-up projects under GMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic and organic chemistry.

Basic Information

Product Name	5-Bromo-1-Methyl-1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylic Acid
CAS No.	916326-81-3
Molecular Formula	C9H6BrN3O2
Molecular Weight	268.07 g/mol
Synonyms	5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid; 1-Methyl-5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid; 916326-81-3; 5-Bromo-1-methyl-pyrazolo[3,4-b]pyridine-3-carboxylic acid; 3-Carboxy-5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid, 5-bromo-1-methyl-
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Methyl-1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with GMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.