Description

1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 5-Bromo-3-Iodo-, 1,1-Dimethylethyl Ester is a high-purity, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of novel pharmaceutical candidates, particularly in kinase inhibitor research. It is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for complex molecular construction.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of targeted small molecule drugs, especially kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Research: Used in the discovery and development of new active ingredients with specific biological activity.
• Chemical Biology: Employed as a molecular probe or scaffold in the study of protein-ligand interactions and biological pathways.
• Material Science: Potential building block for creating novel organic electronic materials or metal-organic frameworks (MOFs) due to its halogenated, electron-deficient structure.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Library Synthesis: Used in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 5-Bromo-3-Iodo-, 1,1-Dimethylethyl Ester
CAS No.	916326-31-3
Molecular Formula	C12H11BrIN3O2
Molecular Weight	435.04 g/mol
Synonyms	5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 5-Bromo-3-iodo-1-(tert-butoxycarbonyl)-1H-pyrazolo[3,4-b]pyridine; 1-Boc-5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine; 916326-31-3; 1H-Pyrazolo[3,4-b]pyridine-1-carboxylic acid, 5-bromo-3-iodo-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 5-Bromo-3-Iodo-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.