Description

(R)-3-Azido-2-(4-Fluorobenzyl)Propanoic Acid is a high-purity chiral building block of significant interest in advanced organic synthesis. Its unique structure, featuring an azido group and a fluorinated aromatic moiety, makes it a versatile intermediate for constructing complex, biologically active molecules. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Peptidomimetic Research: Used to incorporate non-natural amino acid analogs into peptide chains, enabling the study of structure-activity relationships and the development of protease-resistant drug candidates.
• Click Chemistry Substrate: The azido functional group allows for efficient, selective conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC), useful in bioconjugation, materials science, and probe development.
• Agrochemical Synthesis: Serves as a precursor in the design and synthesis of novel herbicides and fungicides, leveraging the fluorobenzyl group for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands and organocatalysts for asymmetric synthesis, facilitating the production of enantiomerically pure compounds.

Basic Information

Product Name	(R)-3-Azido-2-(4-Fluorobenzyl)Propanoic Acid
CAS No.	916322-96-8
Molecular Formula	C₁₀H₁₀FN₃O₂
Molecular Weight	223.20 g/mol
Synonyms	(R)-3-Azido-2-(4-fluorobenzyl)propanoic acid; (R)-2-(4-Fluorobenzyl)-3-azidopropanoic acid; (R)-3-Azido-2-(p-fluorobenzyl)propionic acid; (R)-α-(4-Fluorobenzyl)-β-azidopropionic acid; (R)-3-Azido-2-[(4-fluorophenyl)methyl]propanoic acid; Azido-FBPA; (R)-AFA
EINECS	Contact for details

Quality Control

Our (R)-3-Azido-2-(4-Fluorobenzyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames due to the presence of the azido group. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.