Description

(R)-3-Azido-2-(4-Methylbenzyl)Propanoic Acid is a high-purity chiral building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of an azido functional group and a carboxylic acid moiety on a stereodefined carbon backbone, enabling its use in click chemistry and peptide mimetic applications. This compound is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures, including potential active pharmaceutical ingredients (APIs) and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and peptidomimetic research.
• Click Chemistry Reagent: The azido group facilitates efficient Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition, CuAAC) for bioconjugation and polymer functionalization.
• Peptide Backbone Modification: Used to introduce non-natural amino acid residues or constrained structures into peptide chains to enhance stability and biological activity.
• Agrochemical Synthesis: Serves as a building block for developing chiral active ingredients with specific biological activity.
• Ligand and Catalyst Development: The chiral center makes it a valuable precursor for synthesizing asymmetric ligands and organocatalysts.
• Material Science Research: Employed in the creation of functionalized polymers and dendrimers with tailored properties.

Basic Information

Product Name	(R)-3-Azido-2-(4-Methylbenzyl)Propanoic Acid
CAS No.	916322-95-7
Molecular Formula	C11H13N3O2
Molecular Weight	219.24 g/mol
Synonyms	(R)-3-Azido-2-(4-Methylbenzyl)Propanoic Acid; (R)-2-(4-Methylbenzyl)-3-azidopropanoic Acid; (R)-3-Azido-2-(p-Tolylmethyl)Propanoic Acid; (R)-α-[(4-Methylphenyl)methyl]-β-azidopropanoic Acid; (2R)-3-Azido-2-[(4-methylphenyl)methyl]propanoic Acid; Azido-PMB-Propanoid Acid (R-enantiomer); (R)-AIDA(p-Me-Bn); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (R)-3-Azido-2-(4-Methylbenzyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee reproducible results in your synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.