Description

(S)-3-Azido-2-(4-Methylbenzyl)Propanamide is a chiral, azide-functionalized organic building block of significant interest in advanced synthetic chemistry. Its core value lies in its unique molecular architecture, which enables its use as a key intermediate in the synthesis of complex, biologically active molecules, particularly through click chemistry and other bioorthogonal reactions. This high-purity intermediate is essential for research and development teams in the pharmaceutical and biotechnology sectors focused on creating novel drug candidates, peptide mimetics, and molecular probes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of protease inhibitors, enzyme modulators, and other small-molecule therapeutics.
• Peptidomimetic Synthesis: Used to introduce azido-functionalized side chains into peptide backbones, enabling further conjugation and structural diversification.
• Click Chemistry Substrate: The azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating efficient bioconjugation and polymer modification.
• Chemical Biology Probes: Serves as a building block for creating activity-based probes and affinity tags to study protein function and interactions.
• Agrochemical Research: Employed as an intermediate in the discovery of new, chiral active ingredients for crop protection.
• Material Science: Used to synthesize functional monomers for advanced polymers with tailored properties.

Basic Information

Product Name	(S)-3-Azido-2-(4-Methylbenzyl)Propanamide
CAS No.	916322-85-5
Molecular Formula	C11H14N4O
Molecular Weight	218.26 g/mol
Synonyms	(S)-3-Azido-2-(4-methylbenzyl)propanamide; (S)-2-(4-Methylbenzyl)-3-azidopropanamide; (S)-3-Azido-2-(p-tolylmethyl)propanamide; (S)-α-(Azidomethyl)-4-methylbenzenepropanamide; L-3-Azido-2-(4-methylbenzyl)propanamide; Azido-P-methylbenzyl-propanamide (S-isomer); (S)-3-Azido-2-((4-methylphenyl)methyl)propanamide
EINECS	Contact for details

Quality Control

Every batch of (S)-3-Azido-2-(4-Methylbenzyl)Propanamide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes chiral purity verification by HPLC. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable performance in your most critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to the presence of an azide functional group, it should be stored separately from strong reducing agents and sources of heat or ignition. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.