Description

(S)-3-Azido-2-(4-Methoxybenzyl)Propanamide CAS NO 916322-84-4 is a chiral, non-natural amino acid derivative featuring a reactive azido group and a protected benzyl side chain. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling the synthesis of complex molecules through click chemistry and other bioorthogonal reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the development of new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, peptidomimetics, and other bioactive molecules.
• Click Chemistry Reagent: The azido group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition reactions with alkynes for bioconjugation and polymer synthesis.
• Agrochemical Research: Used in the development of novel chiral pesticides and herbicides with improved efficacy and selectivity.
• Peptide Modification: Incorporation into peptide chains to introduce functional handles or alter physicochemical properties.
• Material Science: Building block for functionalized polymers and dendrimers with specific optical or biological properties.
• Chemical Biology Probe Development: Used to create activity-based probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	(S)-3-Azido-2-(4-Methoxybenzyl)Propanamide
CAS No.	916322-84-4
Molecular Formula	C12H16N4O2
Molecular Weight	248.28 g/mol
Synonyms	(S)-3-Azido-2-(4-Methoxybenzyl)propionamide; (2S)-3-Azido-2-[(4-methoxyphenyl)methyl]propanamide; L-3-Azido-2-(4-methoxybenzyl)propanamide; (S)-2-(4-Methoxybenzyl)-3-azidopropanamide; Azido-PMB-Propanamide; N/A
EINECS	Contact for details

Quality Control

Our (S)-3-Azido-2-(4-Methoxybenzyl)Propanamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation. Keep away from heat, sparks, and open flame. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.