Description

5-Cyano-2-Fluorobenzamide is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a cyano and a fluorinated amide group, makes it a versatile intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of monomers and polymers for advanced materials with specific electronic or optical properties.
• Fluorine Chemistry Building Block: Essential for introducing the valuable fluorine substituent into complex molecular architectures in medicinal and synthetic chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for custom synthesis projects and scale-up activities.

Basic Information

Product Name	5-Cyano-2-Fluorobenzamide
CAS No.	916213-61-1
Molecular Formula	C8H5FN2O
Molecular Weight	164.14 g/mol
Synonyms	2-Fluoro-5-cyanobenzamide; 5-Cyano-2-fluorobenzoic acid amide; Benzamide, 5-cyano-2-fluoro-; 916213-61-1; 2-Fluoro-5-carbamoylbenzonitrile; 5-Carbamoyl-2-fluorobenzonitrile; Amide of 2-fluoro-5-cyanobenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 5-Cyano-2-Fluorobenzamide is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.