Description

tert-Butyl ((2-(Trifluoromethyl)Pyridin-4-Yl)Methyl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core and carbamate protecting group. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the (2-(trifluoromethyl)pyridin-4-yl)methyl moiety into novel drug candidates.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides, where the trifluoromethylpyridine group can enhance biological activity and stability.
• Peptide & Protein Modification: The carbamate protecting group is valuable in solid-phase peptide synthesis (SPPS) and for modifying biomolecules.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands for catalysis and metal-organic frameworks (MOFs) due to its nitrogen-containing heterocyclic structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	tert-Butyl ((2-(Trifluoromethyl)Pyridin-4-Yl)Methyl)Carbamate
CAS No.	916210-33-8
Molecular Formula	C12H15F3N2O2
Molecular Weight	276.26 g/mol
Synonyms	Boc-4-Pic-(2-CF3)-amine; N-Boc-1-(2-(Trifluoromethyl)pyridin-4-yl)methanamine; tert-Butyl N-[(2-(trifluoromethyl)pyridin-4-yl)methyl]carbamate; 1-(2-(Trifluoromethyl)pyridin-4-yl)-N-(tert-butoxycarbonyl)methanamine; 4-((((tert-Butoxy)carbonyl)amino)methyl)-2-(trifluoromethyl)pyridine; (2-(Trifluoromethyl)pyridin-4-yl)methyl carbamic acid tert-butyl ester; Boc-A2P(2-CF3) (abbreviation); BOC-4-(Aminomethyl)-2-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl ((2-(Trifluoromethyl)Pyridin-4-Yl)Methyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.