Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-5-Chloro-1-[(4-Methylphenyl)Sulfonyl]- is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical agents and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this specific halogenated pyrrolopyridine scaffold into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its halogenated structure.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Material Science Research: Acts as a building block for creating novel organic electronic materials or ligands for catalytic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring this specific scaffold.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-5-Chloro-1-[(4-Methylphenyl)Sulfonyl]-
CAS No.	916176-53-9
Molecular Formula	C14H10BrClN2O2S
Molecular Weight	385.66 g/mol
Synonyms	4-Bromo-5-chloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine; 4-Bromo-5-chloro-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(4-Methylbenzenesulfonyl)-4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine; 4-Bromo-5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 916176-53-9; 1H-Pyrrolo[2,3-b]pyridine, 4-bromo-5-chloro-1-[(4-methylphenyl)sulfonyl]-; 4-Bromo-5-chloro-1-tosyl-7-azaindole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-5-Chloro-1-[(4-Methylphenyl)Sulfonyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.