Description

3-[(2S)-1-Methyl-2-Pyrrolidinyl]-5-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]-Pyridine is a sophisticated chiral organosilicon intermediate featuring a protected acetylene moiety. This compound is critical for advanced pharmaceutical research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its unique stereochemistry and functional groups.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant scale.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis or diagnostic applications.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Item	Details
Product Name	3-[(2S)-1-Methyl-2-Pyrrolidinyl]-5-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]-Pyridine
CAS No.	916046-39-4
Molecular Formula	C22H34N2Si
Molecular Weight	354.61 g/mol
Synonyms	(S)-3-(1-Methylpyrrolidin-2-yl)-5-((triisopropylsilyl)ethynyl)pyridine; 5-[(Triisopropylsilyl)ethynyl]-3-[(2S)-1-methyl-2-pyrrolidinyl]pyridine; TIPS-Ethynyl-Nicotine Derivative; (S)-N-Methyl-5-(triisopropylsilylethynyl)nicotine; 916046-39-4; TIPS-protected acetylene pyridine derivative
EINECS	Contact for details

Quality Control

Every batch of 3-[(2S)-1-Methyl-2-Pyrrolidinyl]-5-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]-Pyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to support your regulatory filings, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for each lot and supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.