Description

(2S,5R)-5-Amino-1,2-Piperidinedicarboxylic Acid 1-(tert-Butyl) 2-Methyl Ester is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold for constructing complex molecules with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients, peptide mimetics, and constrained analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Peptidomimetics Development: Used to introduce constrained, non-natural amino acid motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor for creating novel herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands and organocatalysts for stereoselective transformations.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for custom synthesis projects.

Basic Information

Product Name	(2S,5R)-5-Amino-1,2-Piperidinedicarboxylic Acid 1-(tert-Butyl) 2-Methyl Ester
CAS No.	915976-35-1
Molecular Formula	C12H22N2O4
Molecular Weight	258.32 g/mol
Synonyms	1-(tert-Butyl) 2-methyl (2S,5R)-5-amino-1,2-piperidinedicarboxylate; (2S,5R)-5-Amino-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester; (2S,5R)-1-Boc-5-amino-piperidine-2-carboxylic acid methyl ester; (2S,5R)-5-Amino-N-Boc-pipecolic acid methyl ester; Methyl (2S,5R)-5-amino-1-(tert-butoxycarbonyl)piperidine-2-carboxylate; (2S,5R)-5-Amino-1-N-Boc-pipecolinic acid methyl ester; (2S,5R)-1-Boc-5-Amino-2-piperidinecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (2S,5R)-5-Amino-1,2-Piperidinedicarboxylic Acid 1-(tert-Butyl) 2-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.