Description

4-(Tetrahydro-2H-Pyran-2-Ylmethoxy)Aniline is a versatile aniline derivative featuring a tetrahydropyran-protected methoxy group, which serves as a key protected intermediate in advanced organic synthesis. This compound is crucial for the development of active pharmaceutical ingredients (APIs) and fine chemicals, where its protected functional group allows for selective reactions and controlled molecular assembly. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the aniline moiety is incorporated into active structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or chain modifier in the production of specialty polymers with tailored thermal or mechanical properties.
• Dye and Pigment Manufacturing: Employed in the synthesis of complex organic dyes and colorants due to its reactive aniline group.
• Academic and R&D: A valuable reagent for methodological research in organic chemistry, including new protection/deprotection strategies.

Basic Information

Product Name	4-(Tetrahydro-2H-Pyran-2-Ylmethoxy)Aniline
CAS No.	915919-91-4
Molecular Formula	C12H17NO2
Molecular Weight	207.27 g/mol
Synonyms	4-[(Tetrahydro-2H-pyran-2-yl)oxy]aniline; 4-(THP-O-Methoxy)aniline; 4-(2-Tetrahydropyranyloxymethoxy)aniline; Benzenamine, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-; 4-Aminophenyl THP methyl ether; 4-(THPOM)Aniline; 4-(2H-Pyran-2-ylmethoxy)aniline (tetrahydro); 4-(Oxan-2-ylmethoxy)aniline
EINECS	Contact for details

Quality Control

Every batch of 4-(Tetrahydro-2H-Pyran-2-Ylmethoxy)Aniline is produced and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.