Description

Methyl 5,5,5-Trifluoro-3-Oxopentanoate is a high-value fluorinated β-keto ester building block, essential for introducing the trifluoromethyl group into complex molecular architectures. Its unique structure offers significant advantages in modulating the lipophilicity, metabolic stability, and binding affinity of target compounds. This intermediate is critically needed by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with trifluoromethyl motifs, particularly in CNS, oncology, and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and coatings with tailored surface properties.
• Ligand and Catalyst Development: Employed in organic synthesis for creating novel chiral ligands and organocatalysts used in asymmetric transformations.
• Fluorine Chemistry Research: A versatile reagent in academic and industrial R&D for exploring new fluorination methodologies and creating fluorinated compound libraries.

Basic Information

Product Name	Methyl 5,5,5-Trifluoro-3-Oxopentanoate
CAS No.	915213-24-0
Molecular Formula	C6H7F3O3
Molecular Weight	184.11 g/mol
Synonyms	Methyl 5,5,5-Trifluoro-3-oxopentanoate; 5,5,5-Trifluoro-3-oxopentanoic Acid Methyl Ester; Methyl 3-Oxo-5,5,5-trifluoropentanoate; 3-Oxo-5,5,5-trifluoropentanoic Acid Methyl Ester; Methyl 5,5,5-Trifluoro-3-oxovalerate; 5,5,5-Trifluoro-3-oxovaleric Acid Methyl Ester; Methyl 3-Keto-5,5,5-trifluoropentanoate; 3-Keto-5,5,5-trifluoropentanoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 5,5,5-Trifluoro-3-Oxopentanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.