Description

(2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid Dibenzyl Amide is a high-purity, non-proteinogenic amino acid derivative featuring a stereochemically defined pyrrolidine scaffold. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the areas of protease inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for targeted therapies.
• Peptidomimetics & Protease Inhibitors: Used to construct constrained peptide analogs and inhibitors that mimic natural peptide substrates.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective chemical reactions to introduce specific chiral centers.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Bioconjugation & Chemical Biology: Potential use in creating labeled probes or conjugates for studying biological processes.
• Academic & Industrial R&D: Fundamental research in organic chemistry and the development of novel synthetic methodologies.

Basic Information

Product Name	(2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid Dibenzyl Amide
CAS No.	915205-76-4
Molecular Formula	C19H22N2O2
Molecular Weight	310.39 g/mol
Synonyms	(2S,4R)-4-Hydroxy-L-proline Dibenzylamide; 4-Hydroxy-L-proline Dibenzylamide; (2S,4R)-4-Hydroxypyrrolidine-2-carboxamide, N,N-dibenzyl-; L-4-Hydroxyproline Dibenzylamide; Dibenzyl (2S,4R)-4-hydroxypyrrolidine-2-carboxamide; 915205-76-4; (2S,4R)-4-Hydroxyproline Dibenzyl Amide
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid Dibenzyl Amide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support cGMP compliance for advanced intermediates and can provide material for regulatory filing support upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.