Description

(4-Chloro-3-Hydroxyphenyl)Boronic Acid is a versatile and highly functionalized boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables Suzuki-Miyaura cross-coupling reactions, and the chloro and hydroxyl substituents provide handles for further chemical elaboration. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex biaryl structures found in active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing biphenyl or substituted phenyl motifs via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific chlorinated phenolic architectures.
• Material Science: Employed in the creation of organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs) where precise molecular geometry is crucial.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of boronic acid-based sensors for diol recognition (e.g., sugars).
• Academic & Contract Research: Serves as a valuable reagent for methodological development in organic synthesis and catalysis studies within R&D laboratories.

Basic Information

Product Name	(4-Chloro-3-Hydroxyphenyl)Boronic Acid
CAS No.	915201-06-8
Molecular Formula	C6H6BClO3
Molecular Weight	172.38 g/mol
Synonyms	4-Chloro-3-hydroxybenzeneboronic acid; (4-Chloro-3-hydroxy-phenyl)boronic acid; 3-Hydroxy-4-chlorophenylboronic acid; B-(4-Chloro-3-hydroxyphenyl)boronic acid; 4-Chloro-3-hydroxybenzeneboronic acid pinacol ester (common protected form); 4-Chloro-3-hydroxy phenyl boronic acid; 4-Chloro-3-hydroxybenzeneboronic acid, 95%
EINECS	Contact for details

Quality Control

Our (4-Chloro-3-Hydroxyphenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.