Description

[(3R,4S)-4-(2,4,5-Trifluorophenyl)Pyrrolidin-3-Yl]Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and fluorinated aromatic system. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex, biologically active molecules. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas such as enzyme inhibition and receptor modulation.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Development: Serves as a core structural motif in the research and production of protease inhibitors for various disease targets.
• Drug Discovery & Medicinal Chemistry: Utilized in lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Synthesis of Fluorinated Bioactive Compounds: The 2,4,5-trifluorophenyl moiety is leveraged to enhance metabolic stability and membrane permeability of candidate drugs.
• Pre-clinical & Clinical Trial Material: Supplied for the production of batches used in non-clinical studies and clinical trial supplies under GMP guidelines.
• Custom Synthesis & Contract Manufacturing: Used by CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	[(3R,4S)-4-(2,4,5-Trifluorophenyl)Pyrrolidin-3-Yl]Carbamic Acid tert-Butyl Ester
CAS No.	915100-83-3
Molecular Formula	C15H18F3N2O2
Molecular Weight	315.31 g/mol
Synonyms	tert-Butyl N-[(3R,4S)-4-(2,4,5-trifluorophenyl)-3-pyrrolidinyl]carbamate; (3R,4S)-1-Boc-4-(2,4,5-trifluorophenyl)-3-aminopyrrolidine; 1-Boc-3-Amino-4-(2,4,5-trifluorophenyl)pyrrolidine; (3R,4S)-4-(2,4,5-Trifluorophenyl)-3-pyrrolidinamine, 1-(1,1-dimethylethyl) ester; BOC-(3R,4S)-4-(2,4,5-Trifluorophenyl)-3-aminopyrrolidine; (3R,4S)-N-Boc-4-(2,4,5-trifluorophenyl)-3-aminopyrrolidine; 915100-83-3; (3R,4S)-4-(2,4,5-Trifluorophenyl)pyrrolidin-3-ylcarbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our [(3R,4S)-4-(2,4,5-Trifluorophenyl)Pyrrolidin-3-Yl]Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess and standard pharmacopeial methods for purity and identity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.