Description

2-Chloro-6-Ethynylpyridine is a versatile and high-value pyridine derivative featuring both a chloro and an ethynyl functional group, making it a crucial building block in advanced organic synthesis. This compound is prized for its role as a key intermediate in the development of complex molecules, particularly in pharmaceutical research and material science. It is essential for chemists and manufacturers in the agrochemical, pharmaceutical, and specialty chemical industries who require a reliable, high-purity intermediate for cross-coupling reactions and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive ethynyl group for structural diversification.
• Ligand and Catalyst Development: Serves as a foundational structure for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic semiconductors, conductive polymers, and advanced organic frameworks due to its π-conjugated system.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl and conjugated systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for bio-conjugation and imaging applications.

Basic Information

Product Name	2-Chloro-6-Ethynylpyridine
CAS No.	914950-09-7
Molecular Formula	C7H4ClN
Molecular Weight	137.57 g/mol
Synonyms	6-Ethynyl-2-chloropyridine; 2-Chloro-6-ethynylpyridine; 2-Chloro-6-ethynyl-pyridine; Pyridine, 2-chloro-6-ethynyl-; 2-Chloro-6-ethinylpyridine; 2-Cl-6-Ethynylpyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Ethynylpyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development as well as scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.