Description

8-Methyl-1,4-dioxaspiro[4.5]decane-8-carbonitrile is a specialized spirocyclic nitrile compound, serving as a versatile and high-value synthetic intermediate in advanced organic chemistry. Its unique spirocyclic acetal-protected structure makes it a critical building block for constructing complex molecular architectures with precise stereochemistry. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and sophisticated fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its spirocyclic framework for bioactive molecule design.
• Fine Chemical Production: Serves as a crucial building block for creating specialty chemicals, flavors, and fragrances requiring specific stereochemical configurations.
• Academic & Industrial R&D: Employed in methodological chemistry research for developing new synthetic routes and catalytic processes involving nitrile and acetal functionalities.
• Material Science Precursor: Investigated for the synthesis of specialized polymers and ligands with unique structural properties.

Basic Information

Product Name	8-Methyl-1,4-dioxaspiro[4.5]decane-8-carbonitrile
CAS No.	914780-97-5
Molecular Formula	C11H15NO2
Molecular Weight	193.24 g/mol
Synonyms	8-Methyl-1,4-dioxaspiro[4.5]decane-8-carbonitrile; 8-Cyano-8-methyl-1,4-dioxaspiro[4.5]decane; 8-Methyl-8-cyano-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decane-8-carbonitrile, 8-methyl-; Spiro[1,3-dioxolane-2,1'-cyclohexane]-8-carbonitrile, 8-methyl-; (CAS 914780-97-5)
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this high-purity intermediate. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and each batch is accompanied by a comprehensive Certificate of Analysis (COA). Our standard pharmaceutical-grade material typically meets a purity specification of ≥98.0% (by HPLC), ensuring consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.