Description

2-Azaspiro[4.5]Decane-3,8-Dione is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile scaffold for medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of proprietary drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Organic Synthesis: Employed in advanced organic reactions, including cyclizations and functional group transformations, due to its reactive ketone groups.
• Academic & Industrial R&D: Essential for chemical research in universities and corporate labs focusing on heterocyclic and spirocyclic chemistry.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	2-Azaspiro[4.5]Decane-3,8-Dione
CAS No.	914780-96-4
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	2-Azaspiro[4.5]decan-3,8-dione; 3,8-Dioxo-2-azaspiro[4.5]decane; 2-Azaspiro[4.5]decane-3,8-dione; 2-Aza-spiro[4.5]decane-3,8-dione; 2-Aza-spiro[4.5]decan-3,8-dione; 2-Azaspiro[4.5]decan-3,8-dione; 2-Azaspiro[4.5]decane-3,8-dione (CAS 914780-96-4)
EINECS	Contact for details

Quality Control

Our 2-Azaspiro[4.5]Decane-3,8-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.